Small RNA Sequencing

State-of-the-art small RNA sequencing for sensitive, unbiased profiling of miRNAs and other small non-coding RNAs across a wide range of sample types.

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What is Small RNA Sequencing?

Small RNA sequencing enables comprehensive profiling of microRNAs (miRNAs), isomiRs and other small non-coding RNAs. It provides sensitive, unbiased detection of known and novel small RNAs to support biomarker discovery, disease research and gene regulation studies.

How We Support Your Small RNA-Seq Project

01

Consultation

Discuss your project goals, sample types and experimental design with our sequencing specialists.

02

Sample Preparation

Submit tissues, cells, biofluids or purified RNA. We perform RNA extraction and quality assessment where required.

03

Library Preparation

High-quality small RNA library preparation optimised for sensitive and reproducible profiling.

04

Sequencing

Sequencing performed at the optimal depth to capture the complexity of your small RNA population.

05

Data Analysis

Comprehensive QC, miRNA quantification, differential expression analysis and optional customised bioinformatics.

Benefits

Applications

miRNA Expression Profiling

Measure known miRNAs with high sensitivity across diverse sample types.

Biomarker Discovery

Identify small RNA signatures associated with disease, treatment response and biological processes.

Novel Small RNA Discovery

Discover previously unannotated small RNAs and investigate their biological roles.

Differential Expression

Compare miRNA expression across experimental groups with confidence.

Gene Regulation

Investigate post-transcriptional gene regulation mediated by small RNAs.

Translational Research

Support biomarker validation and translational research projects.

Small RNA Solutions for Your Workflow

Choose the Lexogen sample preparation approach that fits your starting material, then continue with the small RNA library preparation strategy that matches your research goals.

Option A · RNA Extraction

Recover the complete RNA size range

SPLIT RNA Extraction Kit

Efficiently isolate both large and small RNAs from diverse sample types, providing high-quality RNA for downstream small RNA sequencing.

Explore SPLIT →
OR
Option B · Small RNA Isolation

Enrich functional small RNAs

TraPR Small RNA Isolation Kit

Rapidly enrich RISC-associated small RNAs from cells, tissues and biofluids for focused downstream small RNA sequencing.

Explore TraPR →
Small RNA-Seq · Library Preparation

Choose your Small RNA-Seq strategy

Select the miRVEL workflow that matches your experimental objective.

Discovery
miRVEL Discovery

For unbiased discovery of known and novel small RNAs, biomarker research and low-input or biofluid samples.

Explore Discovery →
Profiling
miRVEL Profiling

For fast, streamlined and reproducible miRNA expression profiling with minimal hands-on time.

Explore Profiling →

Our Small RNA Offer

Discover Lexogen's innovative portfolio of solutions for RNA extraction, small RNA enrichment and library preparation, supporting reliable and reproducible small RNA sequencing from a wide range of sample types.

TraPR Small RNA Isolation Kit

Rapid enrichment of functional small RNAs. Enrich RISC-associated small RNAs from cells, tissues and biofluids in just 15 minutes, providing high-quality input for downstream small RNA sequencing.

Learn More →

miRVEL Discovery Small RNA-Seq Library Prep Kit

Unbiased discovery of known and novel small RNAs. Designed for biomarker discovery and research applications, enabling sensitive profiling from low-input and biofluid samples without gel-size selection.

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miRVEL Profiling Small RNA-Seq Library Prep Kit

Fast, streamlined miRNA expression profiling. A simplified workflow for robust and reproducible small RNA sequencing, ideal for routine profiling studies with minimal hands-on time.

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SPLIT RNA Extraction Kit

Recover the complete RNA size range from a single extraction. Efficiently isolate both large and small RNAs from diverse sample types, providing high-quality RNA for transcriptomics and small RNA sequencing.

Learn More →

Ready to Start Your Small RNA-Seq Project?

Our scientists will help design the optimal small RNA sequencing workflow for your samples and research objectives.

Talk to Our Experts